Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 7801.037 | 0.4552 | -0.7902 | 0.3490 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 7801.037 | 0.2131 | -0.9762 | 0.3490 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9186.037 | 1.0381 | 1.1493 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9186.037 | 1.0641 | 1.2539 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9186.037 | 1.0179 | 1.0694 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9186.037 | 0.9660 | 0.8712 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9186.037 | 0.7504 | 0.1513 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9186.037 | 0.7385 | 0.1164 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 4 | uM | 9186.037 | 0.6342 | -0.1672 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9186.037 | 0.3966 | -0.6624 | 0.5199 | |
| BT-483 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9186.037 | 0.0727 | -0.9871 | 0.5199 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7803.04 | 0.9655 | 0.9757 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7803.04 | 0.9381 | 0.9561 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7803.04 | 0.9975 | 0.9983 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7803.04 | 0.7535 | 0.8125 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7803.04 | 0.0852 | -0.1509 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7803.04 | 0.0834 | -0.1572 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7803.04 | 0.0936 | -0.1226 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7803.04 | 0.1137 | -0.0613 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7803.04 | 0.0593 | -0.2512 | 2.8752 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7804.04 | 1.0192 | 1.0151 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7804.04 | 1.0126 | 1.0099 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7804.04 | 1.0128 | 1.0100 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7804.04 | 0.6772 | 0.7154 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7804.04 | 0.0922 | -0.2177 | 2.5402 |