Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7804.04 | 0.0972 | -0.2011 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 7804.04 | 0.1221 | -0.1260 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 7804.04 | 0.1615 | -0.0242 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 7804.04 | 0.0499 | -0.3858 | 2.5402 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9024.05 | 0.9652 | 0.9764 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9024.05 | 0.8660 | 0.9060 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9024.05 | 0.8860 | 0.9206 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9024.05 | 0.3950 | 0.4656 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9024.05 | 0.0922 | -0.0995 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9024.05 | 0.0864 | -0.1190 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 9024.05 | 0.0993 | -0.0769 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 9024.05 | 0.1005 | -0.0731 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 9024.05 | 0.0683 | -0.1856 | 2.9873 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 10261.037 | 1.0958 | 1.0850 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 10261.037 | 1.0691 | 1.0617 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 10261.037 | 1.0692 | 1.0619 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 10261.037 | 0.3180 | 0.1873 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 10261.037 | 0.1162 | -0.2491 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 10261.037 | 0.1283 | -0.2145 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 4 | uM | 10261.037 | 0.1523 | -0.1507 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 20 | uM | 10261.037 | 0.1519 | -0.1518 | 2.1973 | |
| BT-549 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 100 | uM | 10261.037 | 0.0082 | -0.7748 | 2.1973 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7805.05 | 0.9660 | 0.9429 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7805.05 | 1.0370 | 1.0618 | 1.1940 | |
| CAMA-1 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7805.05 | 0.9812 | 0.9684 | 1.1940 |