Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7517.065 | 0.0078 | -0.9205 | 1.5040 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7518.065 | 1.0057 | 1.0083 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7518.065 | 1.0782 | 1.1132 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7518.065 | 1.0408 | 1.0594 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7518.065 | 0.9650 | 0.9486 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7518.065 | 0.5548 | 0.2999 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7518.065 | 0.0326 | -0.8363 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7518.065 | 0.0223 | -0.8760 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7518.065 | 0.0226 | -0.8750 | 1.3677 | |
| MDA-MB-453 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7518.065 | 0.0118 | -0.9220 | 1.3677 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7523.065 | 1.0458 | 1.1204 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7523.065 | 1.0319 | 1.0835 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7523.065 | 1.0569 | 1.1496 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7523.065 | 1.0242 | 1.0632 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 8 | uM | 7523.065 | 0.9317 | 0.8236 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 40 | uM | 7523.065 | 0.4336 | -0.3275 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 200 | uM | 7523.065 | 0.0692 | -0.9386 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 1000 | uM | 7523.065 | 0.0320 | -0.9775 | 0.7668 | |
| MX1 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 5000 | uM | 7523.065 | 0.0342 | -0.9755 | 0.7668 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7526.065 | 0.8056 | 0.7410 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7526.065 | 0.9729 | 0.9651 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7526.065 | 0.8790 | 0.8411 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7526.065 | 0.8425 | 0.7918 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7526.065 | 0.6394 | 0.5011 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7526.065 | 0.0208 | -0.8335 | 1.5585 |