Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7526.065 | 0.0202 | -0.8362 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7526.065 | 0.0201 | -0.8369 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7526.065 | 0.0149 | -0.8655 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7527.065 | 1.0099 | 1.0107 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7527.065 | 0.9193 | 0.9107 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7527.065 | 0.9047 | 0.8942 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7527.065 | 0.9051 | 0.8947 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7527.065 | 0.4822 | 0.3463 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7527.065 | 0.0192 | -0.7659 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7527.065 | 0.0161 | -0.7872 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7527.065 | 0.0200 | -0.7604 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7527.065 | 0.0191 | -0.7668 | 1.8429 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7528.065 | 0.9509 | 0.9116 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7528.065 | 0.9652 | 0.9372 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7528.065 | 0.9456 | 0.9019 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7528.065 | 1.0234 | 1.0420 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7528.065 | 0.9359 | 0.8844 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7528.065 | 0.7839 | 0.6070 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7528.065 | 0.0913 | -0.7673 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7528.065 | 0.0335 | -0.9054 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7528.065 | 0.0790 | -0.7956 | 1.1128 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 9044.065 | 0.9674 | 0.8915 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 9044.065 | 1.0212 | 1.0718 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 9044.065 | 1.0046 | 1.0154 | 0.5944 | |
| SUM1315MO2 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 9044.065 | 1.0281 | 1.0955 | 0.5944 |