Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 10380.065 | 0.0184 | -0.8629 | 1.4916 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7482.065 | 0.9797 | 0.9817 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7482.065 | 0.9904 | 0.9914 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7482.065 | 0.9757 | 0.9781 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7482.065 | 0.9025 | 0.9104 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 8 | uM | 7482.065 | 0.6466 | 0.6461 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 40 | uM | 7482.065 | 0.0671 | -0.4017 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 200 | uM | 7482.065 | 0.0139 | -0.7042 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 1000 | uM | 7482.065 | 0.0130 | -0.7127 | 2.2390 | |
| MB 157 | Unknown | Unknown | Trichostatin A | HDAC | HDAC | 5000 | uM | 7482.065 | 0.0091 | -0.7553 | 2.2390 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7483.065 | 0.9686 | 0.9792 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7483.065 | 0.9695 | 0.9798 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7483.065 | 0.9958 | 0.9972 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7483.065 | 0.9088 | 0.9382 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7483.065 | 0.7347 | 0.8076 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7483.065 | 0.2349 | 0.2435 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7483.065 | 0.0316 | -0.3562 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7483.065 | 0.0166 | -0.4787 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7483.065 | 0.0132 | -0.5162 | 3.0487 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7484.065 | 1.0665 | 1.0547 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7484.065 | 1.1011 | 1.0824 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7484.065 | 1.0854 | 1.0699 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7484.065 | 0.9196 | 0.9309 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7484.065 | 0.7454 | 0.7682 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7484.065 | 0.2692 | 0.1539 | 2.3857 |