Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 10379.065 | 0.9643 | 0.9679 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 10379.065 | 1.1345 | 1.1157 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 10379.065 | 1.0502 | 1.0442 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 10379.065 | 1.0210 | 1.0186 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 10379.065 | 0.3733 | 0.2891 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 10379.065 | 0.0137 | -0.7048 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 10379.065 | 0.0144 | -0.6977 | 2.2436 | |
| Hs 578T | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 10379.065 | 0.0139 | -0.7030 | 2.2436 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7477.065 | 1.2059 | 1.5354 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7477.065 | 1.7380 | 3.0293 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7477.065 | 1.1008 | 1.2587 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7477.065 | 1.3402 | 1.8986 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7477.065 | 0.6612 | 0.1841 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7477.065 | 0.0830 | -0.9146 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7477.065 | 0.0139 | -0.9911 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7477.065 | 0.0633 | -0.9394 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7477.065 | 0.0014 | -0.9995 | 0.7891 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 10380.065 | 1.0699 | 1.0927 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 10380.065 | 1.0915 | 1.1209 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 10380.065 | 1.0819 | 1.1084 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 10380.065 | 1.0128 | 1.0171 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 10380.065 | 0.8700 | 0.8217 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 10380.065 | 0.1292 | -0.4927 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 10380.065 | 0.0250 | -0.8316 | 1.4916 | |
| LY2 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 10380.065 | 0.0255 | -0.8291 | 1.4916 |