Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7484.065 | 0.0315 | -0.5308 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7484.065 | 0.0140 | -0.6662 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7484.065 | 0.0053 | -0.7775 | 2.3857 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7485.065 | 1.0593 | 1.0324 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7485.065 | 0.9415 | 0.9667 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7485.065 | 1.0338 | 1.0186 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7485.065 | 0.9999 | 1.0000 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7485.065 | 0.7043 | 0.8138 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7485.065 | 0.2515 | 0.3612 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7485.065 | 0.0482 | -0.1410 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7485.065 | 0.0116 | -0.4227 | 3.5869 | |
| MCF 10A | NM | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7485.065 | 0.0081 | -0.4782 | 3.5869 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7486.065 | 1.0782 | 1.1351 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7486.065 | 1.0527 | 1.0912 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7486.065 | 1.0121 | 1.0210 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7486.065 | 1.1304 | 1.2247 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 8 | uM | 7486.065 | 1.2645 | 1.4520 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 40 | uM | 7486.065 | 0.8054 | 0.6573 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 200 | uM | 7486.065 | 0.1813 | -0.5460 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 1000 | uM | 7486.065 | 0.0428 | -0.8705 | 1.1517 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 5000 | uM | 7486.065 | 0.0258 | -0.9164 | 1.1517 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7490.065 | 1.0084 | 1.0068 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7490.065 | 0.9632 | 0.9700 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7490.065 | 0.9906 | 0.9924 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7490.065 | 1.0151 | 1.0121 | 2.4816 |