Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7450.065 | 0.0211 | -0.5935 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7451.065 | 1.0139 | 1.0129 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7451.065 | 0.9907 | 0.9914 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7451.065 | 0.9632 | 0.9655 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7451.065 | 0.8962 | 0.9008 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7451.065 | 0.6874 | 0.6804 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7451.065 | 0.0327 | -0.5918 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7451.065 | 0.0132 | -0.7317 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7451.065 | 0.0124 | -0.7397 | 2.1525 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7451.065 | 0.0166 | -0.7024 | 2.1525 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7453.065 | 1.0220 | 1.0263 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7453.065 | 1.0247 | 1.0295 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7453.065 | 0.9999 | 0.9998 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7453.065 | 0.9763 | 0.9714 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7453.065 | 0.8191 | 0.7741 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7453.065 | 0.3079 | -0.0143 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7453.065 | 0.1517 | -0.3556 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7453.065 | 0.0653 | -0.6116 | 1.6649 | |
| HCC1937 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7453.065 | 0.0313 | -0.7504 | 1.6649 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7454.065 | 1.0139 | 1.0264 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7454.065 | 0.8125 | 0.6409 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7454.065 | 0.9578 | 0.9195 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7454.065 | 0.9149 | 0.8374 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7454.065 | 0.6153 | 0.2588 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7454.065 | 0.1280 | -0.7182 | 1.0489 |