Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7448.065 | 1.0289 | 1.0219 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7448.065 | 1.0109 | 1.0083 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7448.065 | 0.9184 | 0.9358 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7448.065 | 0.6169 | 0.6621 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7448.065 | 0.1093 | -0.1436 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7448.065 | 0.0594 | -0.3219 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7448.065 | 0.0481 | -0.3745 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7448.065 | 0.0903 | -0.2040 | 2.6104 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7449.065 | 0.8160 | 0.8134 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7449.065 | 0.9889 | 0.9893 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7449.065 | 1.0333 | 1.0318 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7449.065 | 1.0029 | 1.0028 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7449.065 | 0.6935 | 0.6768 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7449.065 | 0.0864 | -0.3849 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7449.065 | 0.0593 | -0.4870 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7449.065 | 0.0431 | -0.5599 | 2.0765 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7449.065 | 0.0707 | -0.4417 | 2.0765 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7450.065 | 0.9234 | 0.9353 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7450.065 | 0.9541 | 0.9616 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7450.065 | 0.9704 | 0.9754 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7450.065 | 0.9806 | 0.9839 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7450.065 | 0.7200 | 0.7464 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7450.065 | 0.0956 | -0.2410 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7450.065 | 0.0171 | -0.6272 | 2.4231 | |
| HCC1806 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7450.065 | 0.0170 | -0.6278 | 2.4231 |