Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5895.065 | 1.0953 | 1.1370 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 8 | uM | 5895.065 | 0.8198 | 0.7309 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 40 | uM | 5895.065 | 0.4606 | 0.1379 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 200 | uM | 5895.065 | 0.1114 | -0.5947 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5895.065 | 0.0129 | -0.9158 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5895.065 | 0.0070 | -0.9456 | 1.3748 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5896.065 | 1.0170 | 1.0227 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5896.065 | 0.9828 | 0.9770 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5896.065 | 0.9863 | 0.9817 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5896.065 | 0.9592 | 0.9452 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 8 | uM | 5896.065 | 0.8647 | 0.8151 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 40 | uM | 5896.065 | 0.5348 | 0.3170 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 200 | uM | 5896.065 | 0.1162 | -0.5248 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5896.065 | 0.0136 | -0.8868 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5896.065 | 0.0141 | -0.8838 | 1.4978 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5897.065 | 0.9602 | 0.9385 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5897.065 | 1.0139 | 1.0214 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5897.065 | 0.9412 | 0.9089 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5897.065 | 0.9874 | 0.9805 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 8 | uM | 5897.065 | 0.9457 | 0.9159 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 40 | uM | 5897.065 | 0.8778 | 0.8091 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 200 | uM | 5897.065 | 0.3697 | -0.0700 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5897.065 | 0.0179 | -0.9094 | 1.2996 | |
| 184B5 | NM | Basal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5897.065 | 0.0142 | -0.9241 | 1.2996 | |
| 600MPE | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5898.065 | 0.9278 | 0.7927 | 0.6845 |