Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7442.065 | 0.9117 | 0.7765 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7442.065 | 0.2425 | -0.6744 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7442.065 | 0.0205 | -0.9863 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7442.065 | 0.0158 | -0.9901 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7442.065 | 0.0170 | -0.9892 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7442.065 | 0.0164 | -0.9897 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7443.065 | 1.0265 | 1.0603 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7443.065 | 1.0041 | 1.0092 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7443.065 | 1.0707 | 1.1610 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7443.065 | 0.7976 | 0.5476 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7443.065 | 0.1274 | -0.8068 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7443.065 | 0.0246 | -0.9700 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7443.065 | 0.0199 | -0.9764 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7443.065 | 0.0207 | -0.9754 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7443.065 | 0.0196 | -0.9769 | 0.8818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7444.065 | 1.0302 | 1.0820 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7444.065 | 1.0398 | 1.1081 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7444.065 | 0.9734 | 0.9287 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7444.065 | 0.7823 | 0.4365 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7444.065 | 0.2141 | -0.7495 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7444.065 | 0.0269 | -0.9847 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7444.065 | 0.0197 | -0.9900 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7444.065 | 0.0234 | -0.9873 | 0.7419 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7444.065 | 0.0235 | -0.9872 | 0.7419 | |
| HCC1569 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7448.065 | 0.9778 | 0.9829 | 2.6104 |