Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7436.065 | 0.6520 | 0.4077 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7436.065 | 0.1979 | -0.4712 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7436.065 | 0.0933 | -0.7149 | 1.2177 | |
| HCC1395 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7436.065 | 0.0377 | -0.8645 | 1.2177 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7437.065 | 0.9962 | 0.9853 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7437.065 | 1.0034 | 1.0130 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7437.065 | 0.9732 | 0.8979 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7437.065 | 0.9499 | 0.8111 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7437.065 | 0.9265 | 0.7260 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7437.065 | 0.5329 | -0.4063 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7437.065 | 0.0393 | -0.9961 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7437.065 | 0.0437 | -0.9952 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7437.065 | 0.0388 | -0.9962 | 0.5183 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7440.065 | 0.9675 | 0.8895 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7440.065 | 0.9354 | 0.7829 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7440.065 | 0.9624 | 0.8726 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7440.065 | 0.9564 | 0.8525 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7440.065 | 0.9057 | 0.6870 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7440.065 | 0.6370 | -0.0788 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7440.065 | 0.0368 | -0.9932 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7440.065 | 0.0257 | -0.9963 | 0.5818 | |
| HCC1419 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7440.065 | 0.0358 | -0.9935 | 0.5818 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7442.065 | 1.0109 | 1.0281 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7442.065 | 1.0072 | 1.0184 | 0.7805 | |
| HCC1428 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7442.065 | 1.0293 | 1.0754 | 0.7805 |