Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 0.0576 | uM | 10267.026 | 0.8711 | 0.2859 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 0.288 | uM | 10267.026 | 1.0137 | 1.0893 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 1.44 | uM | 10267.026 | 0.9713 | 0.8221 | 0.3125 | |
| UACC-812 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 7.2 | uM | 10267.026 | 0.7929 | -0.0483 | 0.3125 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.0000184 | uM | 9997.026 | 1.0203 | 1.0358 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.0000922 | uM | 9997.026 | 0.9968 | 0.9944 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.000461 | uM | 9997.026 | 1.0117 | 1.0206 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.0023 | uM | 9997.026 | 1.0538 | 1.0945 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.0115 | uM | 9997.026 | 1.0291 | 1.0512 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.0576 | uM | 9997.026 | 1.0599 | 1.1053 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 0.288 | uM | 9997.026 | 0.9745 | 0.9550 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 1.44 | uM | 9997.026 | 1.0446 | 1.0785 | 1.1348 | |
| ZR75B | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 7.2 | uM | 9997.026 | 0.8929 | 0.8100 | 1.1348 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5894.065 | 1.0115 | 1.0142 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5894.065 | 0.9581 | 0.9474 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5894.065 | 1.0281 | 1.0348 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5894.065 | 0.9988 | 0.9986 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 8 | uM | 5894.065 | 0.8456 | 0.8018 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 40 | uM | 5894.065 | 0.4418 | 0.2027 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 200 | uM | 5894.065 | 0.1498 | -0.3865 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5894.065 | 0.0459 | -0.7064 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5894.065 | 0.0161 | -0.8469 | 1.6064 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5895.065 | 1.0967 | 1.1389 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5895.065 | 1.0927 | 1.1332 | 1.3748 | |
| 184A1 | NM | Basal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5895.065 | 1.0924 | 1.1328 | 1.3748 |