Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7454.065 | 0.0381 | -0.9113 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7454.065 | 0.0309 | -0.9272 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7454.065 | 0.0304 | -0.9285 | 1.0489 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7455.065 | 0.9821 | 0.9794 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7455.065 | 0.9361 | 0.9256 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7455.065 | 1.0077 | 1.0088 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7455.065 | 0.8860 | 0.8660 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7455.065 | 0.6861 | 0.6114 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7455.065 | 0.1153 | -0.4204 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7455.065 | 0.0223 | -0.7743 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7455.065 | 0.0175 | -0.8035 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7455.065 | 0.0138 | -0.8283 | 1.7441 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7456.065 | 0.8368 | 0.8288 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7456.065 | 0.9716 | 0.9713 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7456.065 | 0.9839 | 0.9838 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7456.065 | 0.9417 | 0.9406 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 7456.065 | 0.8249 | 0.8156 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 7456.065 | 0.1092 | -0.3428 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 7456.065 | 0.0326 | -0.6418 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 7456.065 | 0.0218 | -0.7075 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 7456.065 | 0.0172 | -0.7406 | 1.9899 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7457.065 | 0.9036 | 0.8763 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7457.065 | 0.8697 | 0.8316 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7457.065 | 1.0007 | 1.0009 | 1.5870 | |
| HCC1954 | HER2amp | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7457.065 | 0.8559 | 0.8132 | 1.5870 |