Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5900.065 | 0.0036 | -0.8443 | 2.2026 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5901.065 | 1.0073 | 1.0072 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5901.065 | 1.0512 | 1.0503 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5901.065 | 0.9731 | 0.9731 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5901.065 | 0.8745 | 0.8711 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 5901.065 | 0.0715 | -0.4611 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 5901.065 | 0.0135 | -0.7649 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 5901.065 | 0.0082 | -0.8167 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5901.065 | 0.0098 | -0.7989 | 2.0114 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5901.065 | 0.0059 | -0.8445 | 2.0114 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5902.065 | 0.8961 | 0.8343 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5902.065 | 0.9391 | 0.9034 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5902.065 | 0.9229 | 0.8774 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5902.065 | 0.9706 | 0.9536 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 5902.065 | 0.8936 | 0.8304 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 5902.065 | 0.3821 | -0.0629 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 5902.065 | 0.0849 | -0.7137 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 5902.065 | 0.0635 | -0.7722 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 5902.065 | 0.0509 | -0.8086 | 1.2690 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5904.065 | 0.9760 | 0.9588 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5904.065 | 0.9423 | 0.9008 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5904.065 | 1.0085 | 1.0146 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5904.065 | 0.9311 | 0.8814 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 5904.065 | 0.8039 | 0.6590 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 5904.065 | 0.1262 | -0.6600 | 1.1681 |