Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 5904.065 | 0.0346 | -0.8879 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 5904.065 | 0.0366 | -0.8823 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 5904.065 | 0.0435 | -0.8633 | 1.1681 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 10385.065 | 1.0929 | 1.2882 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.064 | uM | 10385.065 | 0.6234 | -0.0227 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 0.32 | uM | 10385.065 | 0.7405 | 0.2686 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1.6 | uM | 10385.065 | 0.8068 | 0.4446 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 8 | uM | 10385.065 | 0.9290 | 0.7888 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 40 | uM | 10385.065 | 0.3021 | -0.6740 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 200 | uM | 10385.065 | 0.0572 | -0.9738 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 1000 | uM | 10385.065 | 0.0427 | -0.9832 | 0.6599 | |
| BT-20 | TNBC | Basal A | Trichostatin A | HDAC | HDAC | 5000 | uM | 10385.065 | 0.0256 | -0.9923 | 0.6599 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5905.065 | 1.0103 | 1.0244 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5905.065 | 1.0134 | 1.0316 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5905.065 | 1.0228 | 1.0541 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5905.065 | 0.9469 | 0.8750 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 5905.065 | 0.8994 | 0.7645 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 5905.065 | 0.0950 | -0.8761 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 5905.065 | 0.0343 | -0.9629 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 5905.065 | 0.0341 | -0.9632 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 5905.065 | 0.0412 | -0.9539 | 0.8461 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 5906.065 | 0.9523 | 0.8569 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 5906.065 | 1.0504 | 1.1550 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 5906.065 | 0.9743 | 0.9224 | 0.6586 | |
| BT-474 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 5906.065 | 0.9612 | 0.8834 | 0.6586 |