Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 8 | uM | 7490.065 | 0.8273 | 0.8529 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 40 | uM | 7490.065 | 0.2922 | 0.2182 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 200 | uM | 7490.065 | 0.0634 | -0.3418 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 1000 | uM | 7490.065 | 0.0280 | -0.5269 | 2.4816 | |
| MCF12A | NM | Basal B | Trichostatin A | HDAC | HDAC | 5000 | uM | 7490.065 | 0.0129 | -0.6533 | 2.4816 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7492.065 | 0.9966 | 0.9957 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7492.065 | 0.9356 | 0.9188 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7492.065 | 0.9685 | 0.9605 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7492.065 | 0.8597 | 0.8202 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7492.065 | 0.7278 | 0.6407 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7492.065 | 0.1406 | -0.4109 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7492.065 | 0.0955 | -0.5370 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7492.065 | 0.0926 | -0.5458 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7492.065 | 0.0897 | -0.5549 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7493.065 | 0.9876 | 0.9804 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7493.065 | 0.9972 | 0.9956 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.32 | uM | 7493.065 | 1.0137 | 1.0216 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1.6 | uM | 7493.065 | 0.8994 | 0.8396 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 8 | uM | 7493.065 | 0.5389 | 0.2283 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 40 | uM | 7493.065 | 0.0830 | -0.7192 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 200 | uM | 7493.065 | 0.0784 | -0.7314 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 1000 | uM | 7493.065 | 0.0629 | -0.7744 | 1.2680 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 5000 | uM | 7493.065 | 0.0629 | -0.7741 | 1.2680 | |
| MDA-MB-134-VI | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.0128 | uM | 7494.065 | 0.9888 | 0.9666 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 0.064 | uM | 7494.065 | 0.9839 | 0.9521 | 0.6688 |