Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7821.05 | 0.9860 | 0.9109 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7821.05 | 0.9365 | 0.6185 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7821.05 | 0.9111 | 0.4809 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7821.05 | 0.8767 | 0.3080 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7821.05 | 0.8838 | 0.3426 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7821.05 | 0.8614 | 0.2357 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7821.05 | 0.8349 | 0.1172 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9278.012 | 1.0410 | 1.2535 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9278.012 | 1.0195 | 1.1180 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9278.012 | 1.0891 | 1.5768 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9278.012 | 0.9872 | 0.9248 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9278.012 | 0.9081 | 0.5025 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9278.012 | 0.9397 | 0.6629 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9278.012 | 0.8649 | 0.3000 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9278.012 | 0.8807 | 0.3720 | 0.3370 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9278.012 | 0.7849 | -0.0252 | 0.3370 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9294.012 | 0.9674 | 0.9280 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9294.012 | 1.0022 | 1.0048 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9294.012 | 0.9862 | 0.9694 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9294.012 | 0.9824 | 0.9610 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9294.012 | 0.9957 | 0.9905 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9294.012 | 0.9792 | 0.9540 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9294.012 | 0.9822 | 0.9606 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9294.012 | 0.8966 | 0.7725 | 0.9035 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9294.012 | 0.8639 | 0.7010 | 0.9035 |