Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9118.012 | 0.8015 | 0.6084 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9118.012 | 0.6353 | 0.2793 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9118.012 | 0.6239 | 0.2568 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9118.012 | 0.6214 | 0.2517 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9118.012 | 0.6494 | 0.3073 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9120.012 | 1.0116 | 1.0338 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9120.012 | 0.9733 | 0.9226 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9120.012 | 0.9612 | 0.8879 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9120.012 | 0.7829 | 0.4004 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9120.012 | 0.7204 | 0.2405 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9120.012 | 0.5339 | -0.1982 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9120.012 | 0.5693 | -0.1196 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9120.012 | 0.5585 | -0.1438 | 0.6867 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9120.012 | 0.4463 | -0.3823 | 0.6867 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7793.012 | 0.9521 | 0.9130 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7793.012 | 0.9580 | 0.9236 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7793.012 | 1.0270 | 1.0490 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7793.012 | 1.0504 | 1.0911 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7793.012 | 1.0636 | 1.1150 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7793.012 | 1.1462 | 1.2635 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7793.012 | 1.0903 | 1.1632 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7793.012 | 1.0214 | 1.0388 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7793.012 | 1.0043 | 1.0078 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7793.036 | 0.9708 | 0.9455 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7793.036 | 0.9549 | 0.9158 | 1.0741 |