Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9258.024 | 0.9491 | 0.8107 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9258.024 | 0.8911 | 0.6056 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9258.024 | 0.6924 | -0.0069 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9258.024 | 0.6913 | -0.0098 | 0.5251 | |
| HCC1395 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9258.024 | 0.8136 | 0.3502 | 0.5251 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7818.05 | 0.9640 | 0.9225 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7818.05 | 0.8681 | 0.7170 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7818.05 | 0.9428 | 0.8769 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7818.05 | 0.8102 | 0.5939 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7818.05 | 0.7842 | 0.5388 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7818.05 | 0.7311 | 0.4268 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7818.05 | 0.8621 | 0.7044 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7818.05 | 0.7853 | 0.5413 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7818.05 | 0.7154 | 0.3938 | 0.9274 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7820.05 | 0.9417 | 0.7345 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7820.05 | 1.0309 | 1.1496 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7820.05 | 0.9848 | 0.9286 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7820.05 | 0.9316 | 0.6907 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7820.05 | 0.8661 | 0.4226 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7820.05 | 0.8523 | 0.3695 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7820.05 | 0.8731 | 0.4500 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7820.05 | 0.8374 | 0.3134 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7820.05 | 0.8214 | 0.2545 | 0.4219 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7821.05 | 0.9946 | 0.9653 | 0.3098 | |
| HCC1419 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7821.05 | 1.0001 | 1.0006 | 0.3098 |