Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 10031.012 | 1.0868 | 1.2485 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 10031.012 | 1.0268 | 1.0758 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 10031.012 | 1.0487 | 1.1384 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 10031.012 | 0.9211 | 0.7817 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 10031.012 | 1.0350 | 1.0992 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 10031.012 | 0.8016 | 0.4654 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 10031.012 | 1.0313 | 1.0887 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 10031.012 | 1.0062 | 1.0176 | 0.7110 | |
| HCC1428 | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 10031.012 | 0.8481 | 0.5863 | 0.7110 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7825.05 | 1.0193 | 1.0209 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7825.05 | 1.0053 | 1.0057 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7825.05 | 1.0692 | 1.0742 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7825.05 | 0.9830 | 0.9815 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7825.05 | 1.0277 | 1.0300 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7825.05 | 0.9590 | 0.9549 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7825.05 | 0.9465 | 0.9410 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7825.05 | 0.8929 | 0.8803 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7825.05 | 0.9353 | 0.9284 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 9347.012 | 1.0548 | 1.0742 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 9347.012 | 0.9995 | 0.9994 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 9347.012 | 1.0743 | 1.1002 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 9347.012 | 1.0568 | 1.0769 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 9347.012 | 1.0275 | 1.0374 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 9347.012 | 0.9294 | 0.9026 | 1.4653 | |
| HCC1569 | HER2amp | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 9347.012 | 1.0092 | 1.0125 | 1.4653 |