Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 133 | uM | 10580.1 | 0.7670 | 0.4338 | 0.7968 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 7553.093 | 0.9169 | 0.8538 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 7553.093 | 0.9420 | 0.8982 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 7553.093 | 0.9387 | 0.8923 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 7553.093 | 0.9630 | 0.9351 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.107 | uM | 7553.093 | 0.9737 | 0.9539 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.533 | uM | 7553.093 | 0.9457 | 0.9047 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 2.67 | uM | 7553.093 | 0.9871 | 0.9774 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 13.3 | uM | 7553.093 | 0.8535 | 0.7412 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 66.7 | uM | 7553.093 | 0.8651 | 0.7619 | 1.1429 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 10444.093 | 0.9138 | 0.8413 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 10444.093 | 0.9312 | 0.8734 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 10444.093 | 0.9168 | 0.8467 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 10444.093 | 0.9749 | 0.9539 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.107 | uM | 10444.093 | 1.0034 | 1.0063 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.533 | uM | 10444.093 | 0.9092 | 0.8327 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 2.67 | uM | 10444.093 | 0.8914 | 0.7998 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 13.3 | uM | 10444.093 | 0.7781 | 0.5888 | 1.0902 | |
| ZR-75-1 | HR+ | Luminal | TPCA-1 | IKK | NFKB | 66.7 | uM | 10444.093 | 0.6308 | 0.3105 | 1.0902 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9047.012 | 0.9605 | 0.8959 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.000213 | uM | 9047.012 | 0.8924 | 0.7202 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.00107 | uM | 9047.012 | 0.8555 | 0.6263 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.00533 | uM | 9047.012 | 0.6538 | 0.1392 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.0267 | uM | 9047.012 | 0.4612 | -0.2825 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.133 | uM | 9047.012 | 0.5000 | -0.2015 | 0.7549 |