Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.667 | uM | 9047.012 | 0.4915 | -0.2195 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 3.33 | uM | 9047.012 | 0.4913 | -0.2199 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 16.7 | uM | 9047.012 | 0.4693 | -0.2658 | 0.7549 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.0000427 | uM | 10002.012 | 1.0210 | 1.0729 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.000213 | uM | 10002.012 | 0.9645 | 0.8793 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.00107 | uM | 10002.012 | 0.9377 | 0.7903 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.00533 | uM | 10002.012 | 0.7352 | 0.1777 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.0267 | uM | 10002.012 | 0.5725 | -0.2346 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.133 | uM | 10002.012 | 0.5082 | -0.3766 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 0.667 | uM | 10002.012 | 0.5264 | -0.3377 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 3.33 | uM | 10002.012 | 0.5390 | -0.3100 | 0.5807 | |
| 184A1 | NM | Basal | Trametinib | MEK | MAPK | 16.7 | uM | 10002.012 | 0.5290 | -0.3319 | 0.5807 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7791.05 | 0.9976 | 0.9938 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7791.05 | 0.9718 | 0.9291 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7791.05 | 0.9581 | 0.8950 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7791.05 | 0.7488 | 0.3887 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7791.05 | 0.7001 | 0.2756 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7791.05 | 0.6763 | 0.2212 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7791.05 | 0.6756 | 0.2195 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7791.05 | 0.6408 | 0.1410 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7791.05 | 0.6048 | 0.0608 | 0.7929 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9118.012 | 1.1364 | 1.2685 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9118.012 | 1.0462 | 1.0909 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9118.012 | 1.0270 | 1.0532 | 1.0154 | |
| 600MPE | HR+ | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9118.012 | 0.8965 | 0.7960 | 1.0154 |