Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 0.000853 | uM | 10385.093 | 1.0288 | 1.0956 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 0.00427 | uM | 10385.093 | 0.9363 | 0.7949 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 0.0213 | uM | 10385.093 | 1.0208 | 1.0689 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 0.107 | uM | 10385.093 | 1.0326 | 1.1083 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 0.533 | uM | 10385.093 | 0.9418 | 0.8122 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 2.67 | uM | 10385.093 | 0.6865 | 0.0776 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 13.3 | uM | 10385.093 | 0.5414 | -0.2709 | 0.6082 | |
| BT-20 | TNBC | Basal A | TPCA-1 | IKK | NFKB | 66.7 | uM | 10385.093 | 0.6705 | 0.0366 | 0.6082 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 5905.093 | 0.9759 | 0.9471 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 5905.093 | 1.0601 | 1.1325 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5905.093 | 0.9901 | 0.9783 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 5905.093 | 1.0232 | 1.0511 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.107 | uM | 5905.093 | 1.0184 | 1.0405 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 0.533 | uM | 5905.093 | 0.9959 | 0.9910 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 2.67 | uM | 5905.093 | 1.0612 | 1.1349 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 13.3 | uM | 5905.093 | 0.9494 | 0.8892 | 0.9101 | |
| BT-474 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 66.7 | uM | 5905.093 | 1.1167 | 1.2579 | 0.9101 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000171 | uM | 5909.093 | 1.0171 | 1.0118 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.000853 | uM | 5909.093 | 1.1038 | 1.0698 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5909.093 | 1.0718 | 1.0487 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.0213 | uM | 5909.093 | 1.0553 | 1.0377 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.107 | uM | 5909.093 | 1.0511 | 1.0349 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 0.533 | uM | 5909.093 | 0.9832 | 0.9883 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 2.67 | uM | 5909.093 | 0.7579 | 0.8165 | 2.8805 | |
| BT-549 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 13.3 | uM | 5909.093 | 0.6299 | 0.7035 | 2.8805 |