Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10874.15 | 0.9421 | 0.8735 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10874.15 | 0.9102 | 0.8042 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10874.15 | 0.5652 | 0.0709 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10874.15 | 0.3714 | -0.3238 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10874.15 | 0.1516 | -0.7464 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10874.15 | 0.0909 | -0.8552 | 0.9133 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12220.16 | 1.1328 | 1.6535 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12220.16 | 1.0025 | 1.0114 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12220.16 | 1.0700 | 1.3317 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12220.16 | 1.0646 | 1.3050 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12220.16 | 1.0930 | 1.4466 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12220.16 | 0.6942 | -0.1259 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12220.16 | 0.4064 | -0.7404 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12220.16 | 0.3599 | -0.8029 | 0.4410 | |
| MX1 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12220.16 | 0.2152 | -0.9386 | 0.4410 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11851.16 | 1.0236 | 1.0404 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11851.16 | 0.9103 | 0.8452 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11851.16 | 1.0754 | 1.1285 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11851.16 | 0.9646 | 0.9392 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11851.16 | 0.9128 | 0.8496 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11851.16 | 0.9470 | 0.9089 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11851.16 | 0.8756 | 0.7848 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11851.16 | 1.0020 | 1.0034 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11851.16 | 0.7239 | 0.5162 | 1.1668 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10875.15 | 0.9700 | 0.9297 | 0.8527 |