Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10875.15 | 1.0366 | 1.0862 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10875.15 | 1.0218 | 1.0513 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10875.15 | 1.0430 | 1.1012 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10875.15 | 0.8421 | 0.6349 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10875.15 | 0.8248 | 0.5955 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10875.15 | 0.7505 | 0.4284 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10875.15 | 0.5504 | -0.0071 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10875.15 | 0.4031 | -0.3108 | 0.8527 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12428.169 | 1.0066 | 1.0169 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12428.169 | 0.9774 | 0.9427 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12428.169 | 1.0679 | 1.1746 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12428.169 | 0.9706 | 0.9254 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12428.169 | 0.9308 | 0.8254 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12428.169 | 0.8556 | 0.6396 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12428.169 | 0.7865 | 0.4730 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12428.169 | 0.5633 | -0.0373 | 0.7851 | |
| SUM1315MO2 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12428.169 | 0.1241 | -0.8598 | 0.7851 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10819.15 | 1.0265 | 1.0248 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10819.15 | 0.9789 | 0.9800 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10819.15 | 0.9841 | 0.9850 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10819.15 | 0.9644 | 0.9662 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10819.15 | 0.9959 | 0.9961 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10819.15 | 0.9504 | 0.9527 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10819.15 | 0.8246 | 0.8265 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10819.15 | 0.6854 | 0.6744 | 2.1256 |