Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10819.15 | 0.3860 | 0.2781 | 2.1256 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11937.16 | 0.9682 | 0.9734 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11937.16 | 0.9873 | 0.9894 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11937.16 | 1.0453 | 1.0370 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11937.16 | 1.0299 | 1.0245 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11937.16 | 0.9141 | 0.9269 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11937.16 | 0.9064 | 0.9202 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11937.16 | 0.6975 | 0.7228 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11937.16 | 0.7130 | 0.7386 | 2.4144 | |
| SUM149PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11937.16 | 0.2956 | 0.2073 | 2.4144 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10520.138 | 1.2808 | 1.1549 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10520.138 | 1.0116 | 1.0070 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10520.138 | 0.9219 | 0.9516 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10520.138 | 1.1348 | 1.0777 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10520.138 | 0.6804 | 0.7808 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10520.138 | 0.2525 | 0.3209 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10520.138 | 0.2699 | 0.3478 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10520.138 | 0.1649 | 0.1618 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10520.138 | 0.0432 | -0.2239 | 3.3183 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11057.15 | 0.9969 | 0.9984 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11057.15 | 1.0069 | 1.0034 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11057.15 | 0.9523 | 0.9758 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11057.15 | 0.9681 | 0.9839 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11057.15 | 0.8534 | 0.9224 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11057.15 | 0.4798 | 0.6648 | 4.0042 |