Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11057.15 | 0.3753 | 0.5658 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11057.15 | 0.2527 | 0.4185 | 4.0042 | |
| SUM159PT | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11057.15 | 0.0678 | 0.0213 | 4.0042 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12269.16 | 1.0191 | 1.0586 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12269.16 | 0.6791 | 0.1094 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12269.16 | 0.8789 | 0.6430 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12269.16 | 0.9733 | 0.9193 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12269.16 | 0.4480 | -0.4112 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12269.16 | 1.0023 | 1.0071 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12269.16 | 0.8492 | 0.5594 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12269.16 | 0.2720 | -0.7246 | 0.6567 | |
| SUM185PE | TNBC | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12269.16 | 0.0441 | -0.9827 | 0.6567 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10579.138 | 0.9932 | 0.9861 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10579.138 | 0.9060 | 0.8095 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10579.138 | 0.9441 | 0.8867 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10579.138 | 0.9797 | 0.9589 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10579.138 | 1.0042 | 1.0084 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10579.138 | 0.9219 | 0.8417 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10579.138 | 0.9628 | 0.9246 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10579.138 | 0.6984 | 0.3897 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10579.138 | 0.0369 | -0.9296 | 0.9860 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12098.16 | 1.0075 | 1.0157 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12098.16 | 1.0349 | 1.0729 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12098.16 | 1.0029 | 1.0060 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12098.16 | 1.0599 | 1.1253 | 0.9575 |