Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12580.169 | 0.0343 | -0.5824 | 2.1524 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11056.15 | 1.0059 | 1.0039 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11056.15 | 1.0224 | 1.0147 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11056.15 | 1.0282 | 1.0185 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11056.15 | 1.0183 | 1.0120 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11056.15 | 0.7607 | 0.8268 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11056.15 | 0.5959 | 0.6850 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11056.15 | 0.5304 | 0.6213 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11056.15 | 0.4413 | 0.5255 | 3.0207 | |
| MCF 10A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11056.15 | 0.2276 | 0.2253 | 3.0207 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12254.16 | 1.0765 | 1.1079 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12254.16 | 1.0743 | 1.1049 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12254.16 | 1.0639 | 1.0903 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12254.16 | 1.0708 | 1.1000 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12254.16 | 1.0212 | 1.0302 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12254.16 | 1.0088 | 1.0125 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12254.16 | 1.0001 | 1.0002 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12254.16 | 0.7902 | 0.6910 | 1.4029 | |
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12254.16 | 0.2911 | -0.1701 | 1.4029 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10817.15 | 1.0363 | 1.0527 | 1.3689 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10817.15 | 1.0073 | 1.0107 | 1.3689 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10817.15 | 1.0095 | 1.0139 | 1.3689 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10817.15 | 1.0236 | 1.0344 | 1.3689 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10817.15 | 1.0169 | 1.0246 | 1.3689 | |
| MCF12A | NM | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10817.15 | 0.5963 | 0.3709 | 1.3689 |