Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10816.15 | 1.4082 | 5.1867 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10816.15 | 1.2755 | 3.4632 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10816.15 | 1.2179 | 2.8323 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10816.15 | 1.2428 | 3.0963 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10816.15 | 1.1589 | 2.2536 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10816.15 | 1.1116 | 1.8355 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10816.15 | 1.0398 | 1.2751 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10816.15 | 0.6632 | -0.4840 | 0.3031 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12319.169 | 0.8471 | 0.6927 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12319.169 | 0.8191 | 0.6365 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12319.169 | 0.9839 | 0.9676 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12319.169 | 0.9314 | 0.8620 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12319.169 | 0.7345 | 0.4665 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12319.169 | 0.7217 | 0.4408 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12319.169 | 0.7637 | 0.5253 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12319.169 | 0.4641 | -0.0756 | 0.9948 | |
| LY2 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12319.169 | 0.0259 | -0.9492 | 0.9948 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12580.169 | 1.0338 | 1.0312 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12580.169 | 1.0195 | 1.0180 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12580.169 | 1.0556 | 1.0509 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12580.169 | 0.9731 | 0.9748 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12580.169 | 0.1656 | -0.1326 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12580.169 | 0.1422 | -0.1920 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12580.169 | 0.1029 | -0.3048 | 2.1524 | |
| MB 157 | Unknown | Unknown | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12580.169 | 0.1398 | -0.1983 | 2.1524 |