Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10696.15 | 1.0156 | 1.0663 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10696.15 | 0.9736 | 0.8904 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10696.15 | 0.8917 | 0.5705 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10696.15 | 0.9125 | 0.6485 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10696.15 | 0.8545 | 0.4354 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10696.15 | 0.6562 | -0.1777 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11855.16 | 0.9809 | 0.9414 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11855.16 | 0.8597 | 0.5837 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11855.16 | 0.9257 | 0.7754 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11855.16 | 0.9571 | 0.8691 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11855.16 | 0.9061 | 0.7176 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11855.16 | 0.9012 | 0.7034 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11855.16 | 0.8361 | 0.5170 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11855.16 | 0.8029 | 0.4250 | 0.6477 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11855.16 | 0.7268 | 0.2219 | 0.6477 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12305.169 | 1.0621 | 1.0473 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12305.169 | 1.0345 | 1.0265 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12305.169 | 1.1427 | 1.1062 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12305.169 | 1.0577 | 1.0440 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12305.169 | 0.6977 | 0.7395 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12305.169 | 0.6638 | 0.7061 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12305.169 | 0.5663 | 0.6042 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12305.169 | 0.1365 | -0.0760 | 2.5786 | |
| BT-549 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12305.169 | 0.0009 | -0.8691 | 2.5786 | |
| CAMA-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10473.138 | 1.0399 | 1.0617 | 1.2872 |