Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12056.16 | 0.9876 | 0.9729 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12056.16 | 0.8812 | 0.7411 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12056.16 | 0.9723 | 0.9393 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12056.16 | 0.6550 | 0.2578 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12178.16 | 0.9552 | 0.8799 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12178.16 | 0.9705 | 0.9206 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12178.16 | 1.0445 | 1.1213 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12178.16 | 0.9859 | 0.9619 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12178.16 | 0.9129 | 0.7680 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12178.16 | 0.9835 | 0.9554 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12178.16 | 0.8577 | 0.6251 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12178.16 | 1.0008 | 1.0021 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12178.16 | 0.7131 | 0.2658 | 0.7392 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12291.169 | 1.0380 | 1.2218 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12291.169 | 0.9888 | 0.9373 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12291.169 | 1.1574 | 2.0197 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12291.169 | 1.0417 | 1.2438 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12291.169 | 0.8931 | 0.4542 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12291.169 | 0.9965 | 0.9805 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12291.169 | 0.9306 | 0.6330 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12291.169 | 0.7437 | -0.1321 | 0.3548 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12291.169 | 0.1724 | -0.9859 | 0.3548 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10696.15 | 1.0193 | 1.0822 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10696.15 | 0.9352 | 0.7364 | 0.4740 | |
| BT-483 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10696.15 | 1.0013 | 1.0054 | 0.4740 |