Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10880.15 | 0.6161 | 0.4729 | 1.5829 | |
| AU565 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10880.15 | 0.2870 | -0.0910 | 1.5829 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10581.138 | 0.9658 | 0.9277 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10581.138 | 0.8744 | 0.7354 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10581.138 | 0.9512 | 0.8970 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10581.138 | 0.9478 | 0.8898 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10581.138 | 0.9336 | 0.8600 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10581.138 | 0.7237 | 0.4210 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10581.138 | 0.7825 | 0.5434 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10581.138 | 0.6424 | 0.2528 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10581.138 | 0.2116 | -0.6125 | 0.9462 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11854.16 | 1.0062 | 1.0094 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11854.16 | 0.9625 | 0.9425 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11854.16 | 0.9925 | 0.9886 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11854.16 | 1.0440 | 1.0669 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11854.16 | 0.9573 | 0.9345 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11854.16 | 0.8185 | 0.7165 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11854.16 | 0.6874 | 0.5023 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11854.16 | 0.7583 | 0.6193 | 1.3102 | |
| BT-20 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11854.16 | 0.6993 | 0.5222 | 1.3102 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12056.16 | 0.9900 | 0.9781 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12056.16 | 1.0035 | 1.0076 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12056.16 | 0.9917 | 0.9818 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12056.16 | 1.0579 | 1.1272 | 0.9124 | |
| BT-474 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12056.16 | 0.9184 | 0.8218 | 0.9124 |