Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 10151.012 | 0.9732 | 0.8537 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 10151.012 | 1.0214 | 1.1219 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 10151.012 | 0.7794 | -0.0045 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 10151.012 | 1.0319 | 1.1840 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 10151.012 | 1.0599 | 1.3537 | 0.3572 | |
| UACC-812 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 10151.012 | 0.9328 | 0.6462 | 0.3572 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9045.05 | 1.1278 | 1.3285 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9045.05 | 0.9543 | 0.8851 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9045.05 | 1.1403 | 1.3610 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9045.05 | 0.8341 | 0.5902 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9045.05 | 0.9893 | 0.9731 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9045.05 | 0.9005 | 0.7517 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9045.05 | 0.9581 | 0.8946 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9045.05 | 0.9958 | 0.9895 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9045.05 | 0.8462 | 0.6194 | 0.7910 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9933.012 | 1.0636 | 1.3234 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9933.012 | 0.8999 | 0.5476 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9933.012 | 1.0588 | 1.2980 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9933.012 | 0.8331 | 0.2831 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9933.012 | 0.9087 | 0.5845 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9933.012 | 0.8791 | 0.4621 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9933.012 | 0.9415 | 0.7275 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9933.012 | 0.9419 | 0.7290 | 0.4114 | |
| UACC-893 | HER2amp | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9933.012 | 0.7906 | 0.1298 | 0.4114 | |
| ZR-75-1 | HR+ | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7931.036 | 1.0258 | 1.0417 | 1.2358 |