Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12098.16 | 0.9616 | 0.9200 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12098.16 | 0.9160 | 0.8249 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12098.16 | 0.8855 | 0.7614 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12098.16 | 0.9377 | 0.8699 | 0.9575 | |
| SUM225CWN | HER2amp | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12098.16 | 0.4849 | -0.0609 | 0.9575 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11058.15 | 0.9553 | 0.9601 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11058.15 | 1.0099 | 1.0087 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11058.15 | 0.9751 | 0.9779 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11058.15 | 1.0093 | 1.0082 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11058.15 | 0.8927 | 0.9024 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11058.15 | 0.4987 | 0.4717 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11058.15 | 0.3901 | 0.3207 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11058.15 | 0.2991 | 0.1747 | 2.2684 | |
| SUM229PE | TNBC | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11058.15 | 0.0642 | -0.4038 | 2.2684 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10695.15 | 1.0224 | 1.0330 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10695.15 | 0.9264 | 0.8901 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10695.15 | 0.9414 | 0.9127 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10695.15 | 0.9667 | 0.9505 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10695.15 | 1.0230 | 1.0339 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10695.15 | 0.7027 | 0.5406 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10695.15 | 0.4713 | 0.1465 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10695.15 | 0.2347 | -0.3154 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10695.15 | 0.1649 | -0.4728 | 1.3520 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11852.16 | 0.9638 | 0.9413 | 1.2383 | |
| SUM52PE | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11852.16 | 0.9649 | 0.9431 | 1.2383 |