Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11939.16 | 0.6419 | 0.5348 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11939.16 | 0.5679 | 0.4266 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11939.16 | 0.5902 | 0.4599 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11939.16 | 0.4481 | 0.2384 | 1.6749 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 5895.093 | 0.9846 | 0.9767 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 5895.093 | 1.0835 | 1.1247 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5895.093 | 1.0189 | 1.0285 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 5895.093 | 1.0315 | 1.0473 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.107 | uM | 5895.093 | 1.0417 | 1.0626 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 0.533 | uM | 5895.093 | 1.0094 | 1.0142 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 2.67 | uM | 5895.093 | 0.7953 | 0.6828 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 13.3 | uM | 5895.093 | 0.6376 | 0.4244 | 1.3259 | |
| 184A1 | NM | Basal | TPCA-1 | IKK | NFKB | 66.7 | uM | 5895.093 | 0.6032 | 0.3659 | 1.3259 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 5897.093 | 1.0223 | 1.0369 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 5897.093 | 1.0619 | 1.1022 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5897.093 | 0.9835 | 0.9726 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.0213 | uM | 5897.093 | 1.0301 | 1.0499 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.107 | uM | 5897.093 | 1.0149 | 1.0246 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 0.533 | uM | 5897.093 | 1.0078 | 1.0129 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 2.67 | uM | 5897.093 | 0.9267 | 0.8776 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 13.3 | uM | 5897.093 | 0.7081 | 0.5018 | 1.2047 | |
| 184B5 | NM | Basal | TPCA-1 | IKK | NFKB | 66.7 | uM | 5897.093 | 0.6933 | 0.4757 | 1.2047 | |
| 600MPE | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000171 | uM | 5898.093 | 0.9295 | 0.8007 | 0.6963 | |
| 600MPE | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.000853 | uM | 5898.093 | 0.9218 | 0.7792 | 0.6963 | |
| 600MPE | HR+ | Luminal | TPCA-1 | IKK | NFKB | 0.00427 | uM | 5898.093 | 0.9139 | 0.7573 | 0.6963 |