Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11938.16 | 0.9254 | 0.7719 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11938.16 | 0.8129 | 0.4474 | 0.6405 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11660.15 | 0.9704 | 0.9405 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11660.15 | 0.8728 | 0.7446 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11660.15 | 0.9520 | 0.9037 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11660.15 | 0.9340 | 0.8674 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11660.15 | 0.9434 | 0.8863 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11660.15 | 0.8318 | 0.6623 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11660.15 | 0.8127 | 0.6240 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 11660.15 | 0.7551 | 0.5084 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 11660.15 | 0.4979 | -0.0071 | 0.9958 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12003.169 | 0.9180 | 0.8444 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12003.169 | 0.9363 | 0.8791 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12003.169 | 0.9794 | 0.9610 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12003.169 | 0.9160 | 0.8405 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12003.169 | 0.7971 | 0.6136 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12003.169 | 0.8157 | 0.6493 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12003.169 | 0.8004 | 0.6198 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12003.169 | 0.5583 | 0.1518 | 1.0562 | |
| ZR-75-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12003.169 | 0.0679 | -0.8432 | 1.0562 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11939.16 | 0.9567 | 0.9479 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11939.16 | 0.9462 | 0.9351 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11939.16 | 0.9941 | 0.9930 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11939.16 | 1.0387 | 1.0458 | 1.6749 | |
| ZR75B | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11939.16 | 0.7325 | 0.6608 | 1.6749 |