Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 12126.16 | 0.9757 | 0.9301 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 12126.16 | 0.8547 | 0.5946 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 12126.16 | 0.9817 | 0.9474 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 12126.16 | 0.9614 | 0.8897 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 12126.16 | 0.8996 | 0.7169 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 12126.16 | 0.9054 | 0.7329 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 12126.16 | 0.9143 | 0.7574 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 12126.16 | 0.9581 | 0.8802 | 0.6930 | |
| MDA-MB-175-VII | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 12126.16 | 0.6922 | 0.1761 | 0.6930 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10643.138 | 1.0687 | 1.2856 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10643.138 | 1.0244 | 1.0990 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10643.138 | 1.0174 | 1.0706 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10643.138 | 1.0257 | 1.1046 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10643.138 | 0.9790 | 0.9165 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10643.138 | 0.9104 | 0.6563 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10643.138 | 0.8906 | 0.5849 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10643.138 | 0.6460 | -0.1681 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10643.138 | 0.0004 | -1.0000 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10999.15 | 0.9892 | 0.9727 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10999.15 | 0.9803 | 0.9505 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10999.15 | 1.0300 | 1.0760 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10999.15 | 0.9295 | 0.8239 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10999.15 | 0.9820 | 0.9547 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10999.15 | 0.8342 | 0.5913 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10999.15 | 0.8207 | 0.5588 | 0.7928 |