Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10999.15 | 0.7437 | 0.3765 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10999.15 | 0.5741 | -0.0069 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12379.169 | 1.0275 | 1.0930 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12379.169 | 0.9858 | 0.9526 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12379.169 | 1.0176 | 1.0593 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12379.169 | 0.9933 | 0.9775 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12379.169 | 0.9367 | 0.7921 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 12379.169 | 0.8478 | 0.5158 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 12379.169 | 0.9145 | 0.7212 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 12379.169 | 0.6405 | -0.0531 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 12379.169 | 0.0290 | -0.9947 | 0.5957 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10938.15 | 0.9186 | 0.8443 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10938.15 | 0.7956 | 0.6079 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10938.15 | 0.9036 | 0.8155 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10938.15 | 0.8744 | 0.7596 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10938.15 | 0.8348 | 0.6834 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10938.15 | 0.8176 | 0.6504 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10938.15 | 0.7949 | 0.6066 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10938.15 | 0.8385 | 0.6907 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10938.15 | 0.5305 | 0.0922 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 12333.169 | 0.9716 | 0.8987 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 12333.169 | 0.9818 | 0.9346 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 12333.169 | 0.9590 | 0.8545 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 12333.169 | 0.9297 | 0.7531 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 12333.169 | 0.7724 | 0.2543 | 0.5536 |