Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000256 | uM | 10580.138 | 0.9893 | 0.9777 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00128 | uM | 10580.138 | 0.8924 | 0.7759 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0064 | uM | 10580.138 | 0.9391 | 0.8731 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.032 | uM | 10580.138 | 0.9499 | 0.8955 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.16 | uM | 10580.138 | 0.9030 | 0.7981 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.8 | uM | 10580.138 | 0.8457 | 0.6791 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 4 | uM | 10580.138 | 0.8756 | 0.7410 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 20 | uM | 10580.138 | 0.7216 | 0.4229 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 100 | uM | 10580.138 | 0.0759 | -0.8643 | 0.9584 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 10754.15 | 1.0242 | 1.0416 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 10754.15 | 0.9268 | 0.8734 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 10754.15 | 0.9195 | 0.8607 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 10754.15 | 0.8948 | 0.8176 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 10754.15 | 0.9859 | 0.9758 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 10754.15 | 0.8269 | 0.6983 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 10754.15 | 0.9137 | 0.8506 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 6.67 | uM | 10754.15 | 0.7081 | 0.4862 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 33.3 | uM | 10754.15 | 0.4117 | -0.0676 | 1.1628 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0000853 | uM | 11938.16 | 0.9168 | 0.7464 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.000427 | uM | 11938.16 | 0.8670 | 0.6004 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.00213 | uM | 11938.16 | 0.9712 | 0.9107 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0107 | uM | 11938.16 | 0.9747 | 0.9215 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.0533 | uM | 11938.16 | 0.9519 | 0.8517 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 0.267 | uM | 11938.16 | 0.9629 | 0.8853 | 0.6405 | |
| UACC-812 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 1.33 | uM | 11938.16 | 0.9181 | 0.7501 | 0.6405 |