Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 11852.158 | 0.8126 | 0.7085 | 1.3172 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10939.153 | 0.9746 | 0.9702 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10939.153 | 1.0049 | 1.0057 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10939.153 | 0.9960 | 0.9953 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10939.153 | 0.9924 | 0.9911 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10939.153 | 0.9682 | 0.9626 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10939.153 | 0.9775 | 0.9736 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10939.153 | 0.9448 | 0.9347 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10939.153 | 0.6407 | 0.5419 | 1.7112 | |
| T47D | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10939.153 | 0.6617 | 0.5711 | 1.7112 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12608.165 | 1.0079 | 1.0118 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12608.165 | 0.9486 | 0.9229 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12608.165 | 1.0032 | 1.0047 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12608.165 | 0.9621 | 0.9432 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12608.165 | 0.9361 | 0.9039 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 0.267 | uM | 12608.165 | 0.9629 | 0.9443 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 1.33 | uM | 12608.165 | 0.9743 | 0.9615 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 6.67 | uM | 12608.165 | 0.9309 | 0.8960 | 1.3403 | |
| T47DKBLUC | Unknown | Unknown | AS-252424 | PI3K | PI3K | 33.3 | uM | 12608.165 | 1.0132 | 1.0197 | 1.3403 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10580.141 | 0.9973 | 0.9928 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10580.141 | 0.8909 | 0.7128 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10580.141 | 1.0004 | 1.0010 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10580.141 | 0.9939 | 0.9836 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 10580.141 | 0.9667 | 0.9111 | 0.7451 | |
| UACC-812 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 10580.141 | 0.9305 | 0.8157 | 0.7451 |