Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 13.3 | uM | 15315.203 | 0.0906 | -0.6954 | 1.2762 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15315.203 | 0.0754 | -0.7361 | 1.2762 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 66.7 | uM | 15315.203 | 0.0754 | -0.7361 | 1.2762 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7482.074 | 1.0208 | 1.0234 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7482.074 | 1.0208 | 1.0234 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7482.074 | 0.9143 | 0.9011 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7482.074 | 0.9143 | 0.9011 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 7482.074 | 0.9243 | 0.9128 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0107 | uM | 7482.074 | 0.9243 | 0.9128 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 7482.074 | 0.7028 | 0.6380 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.0533 | uM | 7482.074 | 0.7028 | 0.6380 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 7482.074 | 0.0793 | -0.5237 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 0.267 | uM | 7482.074 | 0.0793 | -0.5237 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 7482.074 | 0.0105 | -0.8487 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 1.33 | uM | 7482.074 | 0.0105 | -0.8487 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7482.074 | 0.0007 | -0.9682 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 6.67 | uM | 7482.074 | 0.0007 | -0.9682 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7482.074 | 0.0057 | -0.8929 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 33.3 | uM | 7482.074 | 0.0057 | -0.8929 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 167 | uM | 7482.074 | 0.0044 | -0.9072 | 1.7663 | |
| MB 157 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 167 | uM | 7482.074 | 0.0044 | -0.9072 | 1.7663 | |
| MCF 10A | NM | Basal B | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7483.074 | 1.1322 | 1.0776 | 3.2613 | |
| MCF 10A | NM | Basal B | Bortezomib | Proteasome | Proteasome | 0.000427 | uM | 7483.074 | 1.1322 | 1.0776 | 3.2613 | |
| MCF 10A | NM | Basal B | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7483.074 | 1.0336 | 1.0203 | 3.2613 | |
| MCF 10A | NM | Basal B | Bortezomib | Proteasome | Proteasome | 0.00213 | uM | 7483.074 | 1.0336 | 1.0203 | 3.2613 |