Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 10267.121 | 1.0585 | 1.2948 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 10267.121 | 0.7342 | -0.0527 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 10267.121 | 0.5896 | -0.4425 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 10267.121 | 0.6214 | -0.3672 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 10267.121 | 0.6612 | -0.2645 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 10267.121 | 0.1269 | -0.9864 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 10267.121 | 0.0629 | -0.9975 | 0.4135 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7931.007 | 0.9860 | 0.9807 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7931.007 | 0.9839 | 0.9778 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7931.007 | 0.8346 | 0.7664 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7931.007 | 0.7505 | 0.6421 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7931.007 | 0.5605 | 0.3437 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7931.007 | 0.4339 | 0.1270 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7931.007 | 0.2813 | -0.1631 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7931.007 | 0.2150 | -0.3043 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7931.007 | 0.1816 | -0.3805 | 1.4557 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7932.043 | 1.0090 | 1.0181 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7932.043 | 0.8867 | 0.7729 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7932.043 | 0.8602 | 0.7200 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7932.043 | 0.5939 | 0.1866 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7932.043 | 0.4675 | -0.0664 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7932.043 | 0.3750 | -0.2514 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7932.043 | 0.3245 | -0.3524 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7932.043 | 0.1518 | -0.6975 | 0.9982 | |
| ZR-75-1 | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7932.043 | 0.1600 | -0.6811 | 0.9982 |