Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7538.078 | 0.9206 | 0.8192 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 7538.078 | 0.4777 | -0.1416 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7538.078 | 0.2441 | -0.6021 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7538.078 | 0.2661 | -0.5608 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7538.078 | 0.4213 | -0.2567 | 0.8734 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7540.078 | 1.0526 | 1.1106 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7540.078 | 0.8587 | 0.7043 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7540.078 | 0.7974 | 0.5769 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7540.078 | 0.5338 | 0.0345 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7540.078 | 0.2352 | -0.5624 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 7540.078 | 0.0967 | -0.8279 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7540.078 | 0.1381 | -0.7500 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7540.078 | 0.1461 | -0.7346 | 0.9523 | |
| SUM52PE | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7540.078 | 0.1429 | -0.7407 | 0.9523 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7926.077 | 1.0380 | 1.0935 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7926.077 | 0.9936 | 0.9844 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7926.077 | 1.0674 | 1.1664 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7926.077 | 0.7708 | 0.4539 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7926.077 | 0.5861 | 0.0391 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.874 | uM | 7926.077 | 0.6904 | 0.2701 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7926.077 | 0.4665 | -0.2144 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7926.077 | 0.0906 | -0.8946 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7926.077 | 0.1728 | -0.7674 | 0.8161 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 10267.121 | 1.1094 | 1.5710 | 0.4135 | |
| UACC-812 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 10267.121 | 1.0229 | 1.1125 | 0.4135 |