Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 10146.121 | 0.1045 | -0.7793 | 1.0246 | |
| SUM185PE | TNBC | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 10146.121 | 0.2359 | -0.5116 | 1.0246 | |
| SUM185PE | TNBC | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 10146.121 | 0.2882 | -0.4062 | 1.0246 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.00028 | uM | 7536.078 | 1.0206 | 1.0353 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.0014 | uM | 7536.078 | 0.8553 | 0.7494 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.00699 | uM | 7536.078 | 1.0536 | 1.0915 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.0349 | uM | 7536.078 | 0.7613 | 0.5833 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.175 | uM | 7536.078 | 0.4080 | -0.0718 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.874 | uM | 7536.078 | 0.1068 | -0.7056 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 4.37 | uM | 7536.078 | 0.2696 | -0.3492 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 21.8 | uM | 7536.078 | 0.2480 | -0.3942 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 109 | uM | 7536.078 | 0.2765 | -0.3350 | 1.1676 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.00028 | uM | 9860.121 | 1.0130 | 1.0148 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.0014 | uM | 9860.121 | 0.9631 | 0.9576 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.00699 | uM | 9860.121 | 1.0104 | 1.0118 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.0349 | uM | 9860.121 | 0.7868 | 0.7445 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.175 | uM | 9860.121 | 0.4356 | 0.2455 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 0.874 | uM | 9860.121 | 0.1524 | -0.3154 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 4.37 | uM | 9860.121 | 0.1756 | -0.2579 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 21.8 | uM | 9860.121 | 0.2391 | -0.1151 | 1.7546 | |
| SUM229PE | TNBC | - | Topotecan | TOP1 | TOP | 109 | uM | 9860.121 | 0.3086 | 0.0233 | 1.7546 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00028 | uM | 7538.078 | 1.0037 | 1.0085 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7538.078 | 1.1611 | 1.3731 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7538.078 | 0.9683 | 0.9275 | 0.8734 | |
| SUM44PE | HER2amp | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7538.078 | 1.0919 | 1.2117 | 0.8734 |