Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 10077.121 | 0.2600 | -0.8739 | 0.4875 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00028 | uM | 7879.077 | 1.0230 | 1.0247 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0014 | uM | 7879.077 | 0.9968 | 0.9965 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.00699 | uM | 7879.077 | 0.8787 | 0.8652 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.0349 | uM | 7879.077 | 0.8540 | 0.8367 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.175 | uM | 7879.077 | 0.8373 | 0.8172 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 0.874 | uM | 7879.077 | 0.4391 | 0.2829 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 4.37 | uM | 7879.077 | 0.1112 | -0.3885 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 21.8 | uM | 7879.077 | 0.1067 | -0.4021 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 109 | uM | 7879.077 | 0.0701 | -0.5235 | 1.8534 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7886.007 | 1.1327 | 1.4155 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7886.007 | 1.0430 | 1.1316 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7886.007 | 1.1014 | 1.3153 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7886.007 | 0.9829 | 0.9485 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7886.007 | 0.6571 | 0.0587 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7886.007 | 0.7603 | 0.3204 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 4.37 | uM | 7886.007 | 0.5491 | -0.1935 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 21.8 | uM | 7886.007 | 0.2567 | -0.7451 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 109 | uM | 7886.007 | 0.3052 | -0.6687 | 0.6601 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.000279 | uM | 7886.043 | 1.0048 | 1.0140 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0014 | uM | 7886.043 | 0.8923 | 0.6956 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.00699 | uM | 7886.043 | 0.9565 | 0.8753 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.0349 | uM | 7886.043 | 0.9399 | 0.8282 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.175 | uM | 7886.043 | 0.9540 | 0.8682 | 0.6905 | |
| MDA-MB-175-VII | HR+ | Luminal | Topotecan | TOP1 | TOP | 0.873 | uM | 7886.043 | 0.9344 | 0.8128 | 0.6905 |