Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7846.05 | 0.9860 | 0.9278 | 0.3833 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7846.05 | 0.9244 | 0.6290 | 0.3833 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7846.05 | 0.8460 | 0.2930 | 0.3833 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 7848.05 | 0.9856 | 0.9353 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 7848.05 | 0.9859 | 0.9367 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 7848.05 | 0.9995 | 0.9978 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 7848.05 | 0.9408 | 0.7415 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 7848.05 | 0.9952 | 0.9783 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 7848.05 | 0.9911 | 0.9598 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 7848.05 | 0.9842 | 0.9293 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 7848.05 | 0.9614 | 0.8293 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 7848.05 | 0.9174 | 0.6452 | 0.4413 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9420.012 | 0.9966 | 0.9788 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9420.012 | 0.9403 | 0.6461 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9420.012 | 0.9565 | 0.7375 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9420.012 | 0.9804 | 0.8784 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9420.012 | 0.9175 | 0.5231 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9420.012 | 0.9873 | 0.9206 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9420.012 | 0.9738 | 0.8387 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9420.012 | 1.0159 | 1.1022 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9420.012 | 0.7137 | -0.3118 | 0.3162 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0000427 | uM | 9421.012 | 0.9538 | 0.8721 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.000213 | uM | 9421.012 | 0.9472 | 0.8540 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00107 | uM | 9421.012 | 0.9549 | 0.8750 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.00533 | uM | 9421.012 | 0.9860 | 0.9610 | 0.7153 |