Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.0267 | uM | 9421.012 | 0.9228 | 0.7875 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.133 | uM | 9421.012 | 0.9698 | 0.9160 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 0.667 | uM | 9421.012 | 0.8929 | 0.7071 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 3.33 | uM | 9421.012 | 0.8430 | 0.5751 | 0.7153 | |
| HCC2185 | TNBC | Luminal | Trametinib | MEK | MAPK | 16.7 | uM | 9421.012 | 0.8849 | 0.6857 | 0.7153 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 7853.036 | 1.0309 | 1.0436 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 7853.036 | 0.9405 | 0.9149 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 7853.036 | 1.0337 | 1.0475 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 7853.036 | 1.0176 | 1.0248 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 7853.036 | 0.9757 | 0.9655 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 7853.036 | 0.9732 | 0.9619 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 7853.036 | 0.9696 | 0.9568 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 7853.036 | 0.9673 | 0.9534 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 7853.036 | 0.9434 | 0.9191 | 1.4117 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0000427 | uM | 10056.012 | 0.9828 | 0.9640 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.000213 | uM | 10056.012 | 0.9854 | 0.9693 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00107 | uM | 10056.012 | 0.9952 | 0.9900 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.00533 | uM | 10056.012 | 0.9825 | 0.9634 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.0267 | uM | 10056.012 | 0.9578 | 0.9117 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.133 | uM | 10056.012 | 0.9814 | 0.9610 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 0.667 | uM | 10056.012 | 0.9771 | 0.9520 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 3.33 | uM | 10056.012 | 0.9702 | 0.9376 | 0.9543 | |
| HCC3153 | TNBC | Basal A | Trametinib | MEK | MAPK | 16.7 | uM | 10056.012 | 0.8912 | 0.7725 | 0.9543 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 7854.05 | 1.0021 | 1.0039 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 7854.05 | 0.8784 | 0.7710 | 1.0664 |