Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 7854.05 | 1.0098 | 1.0184 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 7854.05 | 0.8515 | 0.7201 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 7854.05 | 0.9857 | 0.9731 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 7854.05 | 1.0102 | 1.0190 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 7854.05 | 1.0699 | 1.1307 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 7854.05 | 1.0546 | 1.1022 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 7854.05 | 0.9003 | 0.8124 | 1.0664 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 9028.05 | 1.1129 | 1.2438 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 9028.05 | 1.1239 | 1.2677 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 9028.05 | 1.0745 | 1.1608 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 9028.05 | 0.9858 | 0.9695 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9028.05 | 1.6245 | 2.3700 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9028.05 | 1.0901 | 1.1945 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9028.05 | 1.1876 | 1.4063 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9028.05 | 1.2912 | 1.6325 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9028.05 | 1.1435 | 1.3102 | 0.9299 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0000427 | uM | 9453.012 | 0.9975 | 0.9958 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.000213 | uM | 9453.012 | 0.9611 | 0.9352 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00107 | uM | 9453.012 | 1.0348 | 1.0576 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.00533 | uM | 9453.012 | 1.0552 | 1.0911 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.0267 | uM | 9453.012 | 1.0070 | 1.0115 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.133 | uM | 9453.012 | 1.1460 | 1.2394 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 0.667 | uM | 9453.012 | 1.0152 | 1.0253 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 3.33 | uM | 9453.012 | 0.9421 | 0.9034 | 1.2055 | |
| HCC38 | TNBC | Basal B | Trametinib | MEK | MAPK | 16.7 | uM | 9453.012 | 0.9728 | 0.9548 | 1.2055 |