Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7833.007 | 0.9762 | 0.9632 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7833.007 | 0.9375 | 0.9028 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7833.007 | 0.7924 | 0.6711 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7833.007 | 0.6887 | 0.4997 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7833.007 | 0.3030 | -0.2045 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7833.007 | 0.1099 | -0.6364 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7833.007 | 0.2496 | -0.3151 | 1.2952 | |
| HCC1937 | TNBC | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7833.007 | 0.2206 | -0.3775 | 1.2952 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.000279 | uM | 7837.007 | 1.0115 | 1.0139 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 7837.007 | 0.9446 | 0.9318 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 7837.007 | 1.1474 | 1.1746 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 7837.007 | 0.8128 | 0.7631 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 7837.007 | 0.7039 | 0.6153 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.873 | uM | 7837.007 | 0.3041 | -0.0307 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 7837.007 | 0.0898 | -0.5386 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 7837.007 | 0.0490 | -0.6809 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 109 | uM | 7837.007 | 0.0240 | -0.7934 | 1.6436 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00028 | uM | 9386.121 | 1.1930 | 1.3247 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0014 | uM | 9386.121 | 1.0769 | 1.1304 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.00699 | uM | 9386.121 | 1.1707 | 1.2877 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.0349 | uM | 9386.121 | 1.0785 | 1.1332 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.175 | uM | 9386.121 | 0.9223 | 0.8668 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 0.874 | uM | 9386.121 | 0.4357 | -0.0152 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 4.37 | uM | 9386.121 | 0.1446 | -0.6156 | 1.1728 | |
| HCC1954 | HER2amp | Basal A | Topotecan | TOP1 | TOP | 21.8 | uM | 9386.121 | 0.1362 | -0.6346 | 1.1728 |